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KMID : 0861020170320040017
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Korea Journal of Herbology
2017 Volume.32 No. 4 p.17 ~ p.24
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Skin elasticity improvement effect of Young persimmon and Heated young persimmon by decreased Advanced glycation end products(AGEs)
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Kim Soo-Hyun
Lee Ah-Reum
Kim Su-Ji
Kim Kyeong-Jo
Kwon Oh-Jun
Choi Joon-Young
Koo Jin-Suk
Roh Seong-Soo
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Abstract
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Objectives : Advanced glycation end products (AGEs) is bind formation of glucose and protein. Acceleration of AGE formation during hyperglycemia is associated with the pathogenesis of diabetic complications and causes kidney and skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from young persimmon (YP) and heated young persimmon (HYP).
Methods : Paeoniae Radix Alba (YP) is prepared by heating with 30% ethanol. AGEs formation inhibitory activities of YP and HYP measured using bovine serum albumin. To evaluate the protective effects of YP and HYP in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rats were distributed into four groups; normal mice (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 ㎎/㎏ YP (YP), AGEs-induced rats treated with 100 ㎎/㎏ heated YP (HYP) for 3weeks. Heated young persimmon respectively decrease AGEs construction.
Results : YP and HYP administration inhibited the biomarkers of AGEs in serum, kidney and skin tissues. AGE-induced rats revealed that the significant decreased collagen however, heat processing methods of young persimmon up regulated inhibits AGEs-induced collagen decrease. The expressions of AGEs were decreased in YP and HYP treated group compared with the control group in tissues. It specifies that HYP has potential to serve as a positive regulator of via AGEs path way.
Conclusion : It has proposed that may have an improvement effect on diabetic complications, heated young persimmon has AGEs inhibitory excellent activities and antioxidant effect.
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KEYWORD
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Young persimmon, Advanced glycation end products (AGEs), Heating, Skin, Collagen
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